A B S T R A C T The instantaneous uptake of CO in the lungs was measured with a water-filled body plethysmograph in normal man. First, control measurements of plethysmograph pressure were made while the subject held his breath for 7 sec after breathing gas mixtures prepared to bring his alveolar Po2 and Pco2 close to mixed venous levels. Then, CO uptake measurements were made while he held his breath after inhaling the same gas mixtures with added CO (2.0%). The change in lung volume on CO minus the change in lung volume during the control measurement was a measure of the CO uptake in the lungs. Cardiopneumatic changes in lung gas volume were subtracted electrically. All of five subjects showed pulsatile CO uptake. The mean CO uptake was 103 ml/min. A peak uptake of 2.0 (range 1.6-2.3) times the mean uptake occurred 0.3-0.4 sec after the R wave of the EKG and a minimum uptake of 0.4 (range 0.2-0.5) times the mean uptake occurred during the tenth of a second before the R wave of the EKG. These results suggest that pulmonary capillary blood volume is pulsatile during the cardiac cycle.

No abstract

No abstract

No abstract

To develop a method for the early diagnosis of health damage due to arc welding, we measured serum ferritin in 96 general employees and 320 arc welders in Company A. A positive correlation was observed between age and the serum ferritin level in the young group (age, 20 -44 years) among the general employees. The mean serum ferritin level in the general employees was 119 ± 56 ng/ml. When the mean ± 2.5 SD was used as the standard value, ferritin levels > 260 ng / ml could be regarded as high. Based on this standard value, high ferritin levels were observed in 7 (6.6%) of 106 young arc welders in Company A but none of the general employees. Chest X-ray films showed minimal abnormality in one of 7 young arc welders who showed high ferritin levels. These results suggest that the determination of the serum ferritin level is useful for the early diagnosis of health damage due to arc welding.