Twoantifungal antibiotics maniwamycins A and B were isolated from the culture broth of a strain of actinomycetes, which were classified as Streptomyces prasinopilosus. These antibiotics were isolated by resin absorption and extraction with EtOAcand purified by column chromatography. Both antibiotics were found to be new azoxy substances from their physico-chemical properties. They showed broad antifungal spectra.In the course of screening for new antifungal agents from culture broths, wehave discovered the novel antifungal antibiotics, maniwamycins A and B^produced by a Streptomyces sp. This paper details the taxonomy of the producing organism, isolation, and physico-chemical and biological properties oi these antibiotics. The structural elucidation of antibiotics maniwamycinsA and B are described in ar accompanying paper. 1}

A new aminoglycoside antibiotic belonging to the apramycin group, KA-5685 has been isolated from the culture broth of Saccharopolyspora hirsuta ATCC 278751). This strain also coproduced apramycin2). In this communication, the isolation, characterization and structural elucidation of the antibiotic KA-5685 are reported. S. hirsuta ATCC 27875 was cultured at 27•‹C for 5 days in 500-ml Erlenmeyer flasks containing 50 ml of a medium, composed of 2 % glycerol,

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