A method for fabricating a low invasive microneedle which is three-dimensionally imitating mouthparts of mosquito was proposed. In this method, the microneedle is fabricated by casting of a thermoset epoxy resin into a micromold. Microneedles made of the thermoset epoxy resin were tried to fabricate using proposed method. As a result, the microneedles with fine-shaped tip were successfully formed when those diameters are larger than 100 µm. It was also confirmed that the fabricated microneedle can puncture into artificial skin (Young's modulus is 0.1 MPa) without buckling.