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Abstract-Effectsof serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypo glycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neitheir the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.in the liver may also contribute to the hypoglycemic effects of 5-HT. In this paper, therefore, to clarify the involvement of insulin in hypoglycemia induced by 5-HT, we investigated the effects of 5-HT on blood glucose and insulin levels using glucose and streptozotocin-treated mice.

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