Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the impact of the expression of CIRP and TLR4 on the prognosis of patients with OSCC and relate that expression to the clinicopathological characteristics of these patients. For the first time, we demonstrated that the expression of CIRP and TLR4 was increased in OSCC and that high levels of CIRP or TLR4 expression were associated with a short survival rate. In addition, we were surprised to find that the levels of expression of CIRP and TLR4 were very similar. The goal of this study was to evaluate whether these two genes may provide clues as to the regulatory mechanisms of OSCC, serve as prognostic markers and establish a new direction for further studies of these biological mechanisms.

Background: The purpose of this study was to evaluate the diagnostic and prognostic significance of serum bone sialoprotein (BSP) in patients with bone metastasis (BM) from non-small cell lung cancer (NSCLC). Patients and Methods: A total of 146 patients diagnosed with NSCLC and 110 healthy controls were enrolled in this study. The clinical characteristics including clinical stage, pathological type, smoking status, and ECOG performance status were obtained. The mean serum BSP was detected by sandwich ELISA. Results: The mean serum BSP level in individuals with BM was significantly higher than those in non-BM NSCLC and controls (p < 0.001). Receiver operating characteristics (ROC) analysis showed that BSP discriminated patients with BM from non-BM NSCLC patients at the cutoff value of 33.56 ng/ml. Sensitivity and specificity were 77.8 and 81.1%, respectively. Kaplan-Meier analysis showed that subjects with higher BSP levels had a shorter BM-free period than those with lower BSP levels. Cox regression analysis revealed that the BSP level was a predictor for prognosis of BM from NSCLC. Conclusion: Serum BSP is a useful biomarker for the diagnosis of BM from NSCLC, and can be regarded as an independent factor for predicting the prognosis of BM from NSCLC.

Background: Parotid gland tumor is the most common salivary gland tumors. Benign tumors account for about 80% of parotid gland tumors. Surgical excision is the treatment of choice in most cases when treating benign parotid tumors. However, due to the special anatomical location of the parotid gland and the different pathology of the tumor, there are many complications after parotid gland tumor operation, which also seriously affects patients quality of life.