A novel and efficient thiolation reaction of aza-heteroaromatic N-oxides with disulfides via copper catalyzed C–H activation has been developed.

The preparation of various aza‐heteroaromatic dithiocarbamates from aza‐heteroaromatic bromides and tetraalkylthiuram disulfides is reported. The transformation provides a convenient procedure, with good yields and functional group tolerance to various important nitrogen‐containing heteroaromatic dithiocarbamates such as benzothiazole, quinoline, pyridine, and pyrazine motifs. This protocol allows the facile synthesis of some potential biologically active compounds.

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