Background: Solanum xanthocarpum grows in parts of India as a wild herb. The active principles of this plant are Solasodine, Carpesterol, β-Sitosterol, and Diosgenin. Pharmacological effects such as hypoglycemic, hepatoprotective and hypotensive activity of S. xanthocarpum have been reported. Solasodine, an active component of this plant is reported to have antioxidant activity. Aims and Objectives: The objective of this study is to evaluate the anticancer and anti-obesity property of S. xanthocarpum. Materials and Methods: This study was carried out in Department of Pharmacology, Government Kilpauk Medical College, with laboratory support from Life Teck Research Center, Chennai. Both dry and fresh leaves of S. xanthocarpum were taken and evaluated for anticancer property using MCF cell line and anti-obesity activity using Pancreatic Lipase inhibition activity. Results: There was significant decrease in cell viability with increase in concentration of both dry and fresh leaves which shows anticancer activity. With increase in concentrations of leaf extracts, the inhibition of pancreatic lipase was found but in comparison to Orlistat the standard treatment, the effect was very less. Conclusion: Based on above results, it is concluded that S. xanthocarpum has good anticancer and minimal anti-obesity activity. Further investigations are required to identify the actual phytoactive component.

This case study is to report and explore the etiology of a case of refractory seizures due to overdosage of phenytoin tablets. A case report from the Department of Neurology generated through voluntary adverse drug reaction (ADR)reporting stated phenytoin overdosage leading to refractory status epilepticus which did not respond to any of the antiepileptic drugs. A 33-year-old female patient with the history of consumption 15 tablets of phenytoin and a metal ring as part of a suicidal bid a month ago, presented with unconsciousness, persistent seizures, and gangrene of fingers. Magnetic resonance imaging showed generalized atrophic changes of the cerebrum and cerebellum. Electroencephalogram suggested multifocal onset status epilepticus. The patient did not respond to standard emergency treatment of status epilepticus with known antiepileptic drugs and was treated with thiopentone infusion under mechanical ventilation, which controlled her seizures as long as she was maintained under the infusion. Causality analysis using the World Health Organization scale categorizes this ADR as "possible", as the patient is a known case of seizure disorder with additional cerebral changes. Hence, the disease could have had an influence over the toxic reaction. To conclude, seizures are a rare complication of phenytoin. Seizures can be prevented by evaluating therapeutic plasma concentration of phenytoin. In this case, the patient was on chronic treatment, and due to intentional toxicity, she progressed to a refractory state of seizures. This could have occurred because of the unique kinetic profile of phenytoin, small therapeutic index, genetic variation in drug metabolizing enzymes, and saturated sodium channels.

Background: Depression and hypertension are common morbidities which are seen in elderly and also one leads to the other. Present antidepressant drugs are known for its side effects and there is a necessary for newer drugs with lesser adverse effects. Telmisartan being a widely used antihypertensive drug and with multiple additional properties like peroxisome proliferator-activated receptor gamma activity along with blunting of renin-angiotensin-aldosterone system can be a potential drug for depression. Hence this study is aimed to evaluate the antidepressant activity of angiotensin receptor blocker telmisartan in animal models.Methods: As per protocol submitted to ethics committee, 24 male albino mice weighing between 20-30grams of either sex were selected and divided into 4 groups consisting of 6 each. They were housed in cages with food and water ad libitum. Animals were kept in ambient temperature and humidity, with a 12-hour light and 12-hour dark cycle.  Group 1 and group 2 were administered distilled water and fluoxetine 10 mg/kg respectively only on day 15, whereas group 3 and group 4 received telmisartan per orally 1 mg/kg and 2 mg/kg respectively for 15 days once daily. All animals were tested on day 15 using tail suspension test for antidepressant effect.Results: There was significant reduction in the immobility time in telmisartan group when compared to the control group and this time was comparable with the immobility time of standard drug fluoxetine. Decrease in immobility time was found to statistically significant by using one-way ANOVA followed by Bonferroni post hoc test.Conclusions: As evident from our study, telmisartan can be a newer target for antidepressant effect.

Background: E-learning or electronic learning is a popular modality to address the educational needs of a population. In the context of medical education, E-learning is useful but has its limitations. Aim and Objectives: This study was conducted among 2-year MBBS students of a Government Medical College in South India to know their knowledge, attitude, and practice of E-learning and also to learn from their experiences during the COVID pandemic. Materials and Methods: After obtaining informed consent, students were asked to fill up a questionnaire containing 15 questions in Google Forms and submit it. Results: This study shows that more than 70% of students consider themselves capable of using computers for everyday activities. They also reported using search engines and online animations for updated medical information. However, they preferred their course content to be delivered through blended learning, a combination of classroom and E-learning. The students reported poor internet connectivity as a major limitation in E-learning. They also suggested having a separate website for each college where the teaching material can be uploaded by the faculty and can be accessed by all the students of the institution. Conclusion: From this study, it can be concluded that a majority of students have good knowledge and are already using E-learning modalities. They are also open to the idea of blended learning for clinical cases.

The ratio of mortality of the Non-communicable disease are been increasing when compared to the communicable disease .This shift is alarming and requires intensive program and also monitoring to see if they meet the needs properly. It is a well established fact that control of hypertension decreases the morbidity and mortality. But still there is no sufcient awareness among patients regarding the importance of BP control and compliance to treatment.This study was to aim on the screening of adherence of the anti hypertensive medications .The clinical audit was conducted as a retrospective analysis of the case records of the hypertensive patients attending as outpatients in the department of Cardiology. Results : Out of 200 patients screened, irrespective of whether they had diabetes or not, it was found that 134 patients (67%) had BP less than or equal to the target and 66 patients (33 %) had BP higher than the target level. Out of 100 Hypertensive patients 83 % patients had adequate control of BP and 17 % had poor control. Out of 100 hypertensive diabetics 51 % had adequate control of BP and rest 49 % had poor control.