Granulomatous mastitis (GM) is a rare disease, particularly among men. Herein, we present a case of GM diagnosed in a 63-year-old male patient who showed reduction in the tumor size during 3 months of observation.

No abstract

A 34-year-old woman with breast cancer and the BRCA2: p.Gln3047Ter was treated with olaparib. After tumor progression, cancer genomic profiling testing revealed the BRCA2 p.Gln3047Ter and p.Gln3047Tyr, with 48.9% and 0.37% allele frequency, respectively. These findings shed light on reversion mutation as a resistance mechanism to olaparib in breast cancer.

Sports are an important part of the national economy, with significant benefits to individual lives and society, contributing significantly to consumption, investment, productive activity and employment. The value-added amount of the sport industry is estimated as a satellite account of the national accounts system (SNA) . In Japan, the Development Bank of Japan has been estimating sport GDP since 2017 in a way that is comparable to European results. Sport GDP represents the total value-added amount generated by sport-related economic activities. However, to analyze how sport participation is linked to economic value, it is essential to take an approach based not only on the value-added amount but also on final demand, such as consumption, investment, and exports. In this paper, we devised a new framework for describing the economic structure of the sport industry and other industries and we developed an input-output table for analyzing the sport sector. The estimation resulted in an output value of 11,374 billion yen and a gross value added of 7,077 billion yen for the sport industry in 2018. With imports from abroad amounting to 962 billion yen, the market size of the sport industry (total supply = total demand) is 12,336 billion yen. The breakdown of total demand is 1,979 billion yen for intermediate demand in the sport industry and 9,687 billion yen for domestic final demand, of which 8,753 billion yen is for consumption and 925 billion yen is for investment. Exports to foreign countries amounted to 670 billion yen.

A rare missense mutation was identified as a reversion mutation using cancer genomic profiling and a suspected mechanism underlying resistance to olaparib in breast cancer.