Three out of fifteen cases of disseminated malignant melanoma with complete or partial responses to our combined chemoimmunotherapy, DTIC, ACNU, VCR and OK432, are reported. Case 1 responded completely with disappearance of skin and brain lesions. Case 2 responded partially to a lung metastasis. Case 3 responded totally with the complete disappearance of lung and brain metastatic lesions. None of these cases suffered any significant side effects during the trial.

A case of a 77-year-old male with Sezary's syndrome (55) is reported, including ultrastructural and immunohistochemical characterization of the cellular infiltrates.Atypical lymphocytes in the skin were evaluated at stages of both clinical exacerbation and improvement. During both stages, skin specimens revealed essentially similar findings. They were diffusely infiltrated by atypical lymphocytes with a characteristic nuclear convolution. The infiltrating cells exhibited T-cell markers which cross-reacted with the T -cells of the lymph nodes. Atypical convoluted cells in the peripheral blood were PA5 positive and peroxidase negative. The morphological and functional characteristics of the cellular infiltrates in 55 and its clinical independence from mycosisfungoides were discussed.