Natural cyclodextrins (CDs) and their derivatives are host molecules that form inclusion complexes with hydrophobic drugs and are widely applied as pharmaceutical additives and DDS carriers in the pharmaceutical field. Recently, supramolecular necklaces using CDs have also been attracting attention, and their functions have been found to be superior to those of conventional low-molecular-weight or high-molecular-weight drug formulation materials. In addition, a paradigm shift is taking place in which CDs themselves are being used as active pharmaceutical ingredients. This paper reviews the creation of CD-based materials and their application to pharmaceuticals.

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