Keishiro Shimura scite author profile

Polysaccharides extracted from Himematsutake, the fruiting body of Agaricus blazei Murill with hot water were fractionated and purified by ethanol precipitation, ion-exchange chromatography, gel-filtration, affinity chromatography, etc. A total of 17 polysaccharide samples thus obtained were given an antitumor activity test (Sarcoma 180/mice up. p.o. method) and traces of their activities through the fractionation and purification processes were found.FI0-a-/J, FA-l-a-a, FA-l-a-/J, and FA-2-b-/?, were obtained as water soluble polysaccharides fractions having great antitumor activities.Analyses of physico-chemical properties and IR-and NMR-spectra of these active fractions showed that their main components were:

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Formolysis of a potent antitumor (1 → 6)-β-d-glucan-protein complex from Agaricus blazei fruiting bodies and antitumor activity of the resulting products

Kawagishi

Kanao

Inagaki

et al. 1990

Carbohydrate Polymers

106

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Antitumor Activity and Some Properties of Water-soluble Polysaccharides from “Himematsutake,” the Fruiting Body ofAgavicus blazeiMurill

Mizuno

Hagiwara

Nakamura

et al. 1990

Agricultural and Biological Chemistry

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Studies on the host-mediated antitumor polysaccharides. Part XIV. Antitumor activity and some properties of water-insoluble hetero-glycans from "Himematsutake," the fruiting body of Agaricus blazei Murill.

Mizuno

Inagaki

KANAO

et al. 1990

Agricultural and Biological Chemistry

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