Background: Specificity of G-protein function may be determined by a specific ␣␤␥ composition. Results: Combinatorial disruption of ␥ 3 and ␥ 7 produces a severe seizure phenotype not observed with either gene alone. Conclusion: This reflects distinct roles for ␥ 3 and ␥ 7 in G i/o -and G olf -signaling pathways that modulate seizure susceptibility. Significance: The ␥ subunits direct the assembly of distinct G-protein ␣␤␥ heterotrimers that specify diverse receptor actions.

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The administration of aspirin to patients undergoing robot-assisted radical prostatectomy and nephrectomy appears to be safe. The risk of cardiovascular complications resulting from stopping aspirin may exceed the risk of perioperative bleeding and associated complications.