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The antimicrobial constituents of the marine sponge Halichondria sp. from Ponape have been identified as (6fl,7S)-7-amino-7,8-dihydro-a-bisabolene (3) and its hydrochloride salt 4. The structure of amine 3 was determined by an X-ray crystallographic study of the corresponding symmetrical urea 5 and the absolute configuration was elucidated by chemical conversion to (6fl,7£)-a-bisabqlene. The urea 5, the corresponding isothiocyanate 6, and an unrelated diene 7 were also isolated from the sponge.

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