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The authors studied mortality among 2513 relatives of 56 Japanese patients with systemic lupus erythematosus. The observed deaths in 142 relatives were compared with the expected number of deaths. The observed number of deaths was significantly less among relatives of patients with systemic lupus erythematosus (p less than 0.01). Deaths from malignant neoplasms and senility (senescence) were significantly lower than the expected number of deaths among relatives (p less than 0.05).

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A case of heterogeneous acute lymphoblastic leukemia of the Burkitt type (L3-ALL) is reported. A 58-year-old womanwas admitted to our hospital with complaints of palpitation and shortness of breath in December 1988. On admission, the peripheral blood showed severe pancytopenia. The bone marrow was hypercellular with abnormal lymphoblasts; the cytoplasm was moderately abundant and intensely basophilic with prominent vacuoles. A diagnosis of L3-ALLwas made. Cytogenetic analysis of bone marrowcells revealed a karyotype of 46,XX. The leukemic blasts were HLA-DR+, CD10+ , CD19+ and CD20+ , but no surface or cytoplasmic immunoglobulins were detected. This is the first report in Japan of a case of L3-ALLwithout chromosome abnormality and lacking surface and cytoplasmic immunoglobulins.

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