These findings indicate that efficient prednisolone doses may vary between sexes and ages, and that a higher initial prednisolone therapy may be of greater benefit to older boys.

No abstract

The purpose of the present study Is to investigate the role of HBe antlgen In the pathogenesbs of membranous glomerulonephr~t~s (MGNI In Japanese chtldren. Of 364 chtldren who underwent renal blopsy from 1976 through 1978 in our inst~tution.Il(lO male, 1 female, qles 1-14 years1 were found to be HBs antigen carrlers and comprise the subject of the present study All of them exhibited some abnormaltty on a routine urinalysis at one tlme during the courre. Serum HB associated antigens were studled in all. A routine Itght. fluorescent and electron microscop~c study was performed on 14 biopsied specimens from the Ilch~ldren. I n addltlon, direct ~mmunofluorescence for HBsAg, HBeAg & HBcAg was done ~n the majority of the specimens. The results are summerized in the table. The 14 soeclmens were divided into 2 urouos de. pend~ng upon clnntcal man~festat~ons at the tome of renal b~opsy I G r o~p A 9 specamens from 9 choldren wltn nepnrot~c syndrome or heavy prote4nur.a. Grodp B 5 specimens from 4 ch Id