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The preparation o f a sustained release dosage form for pseudoephedrine hydrochloride was evaluated. Beadlets (PS containing pseudoephedrine hydrochloride were prepared by spraying a slurry of pseudoephedrine hydrochloride, Eudrag t n 5-100, dibutyl sebacate and alcohol onto non-pariel seeds via the Wurster column process. The oven-dried PS beadlets were coated with different levels of Eudragitk RS (poorly water permeable) d e t e r m i n i n g t h e r e l e a s e r a t e p r o f i l e s o f t h e d r u g from t h e c o a t e d b e a d l e t s . Drug r e l e a s e from t h e c o a t e d b e a d l e t s a p p e a r e d t o f o l l o w f i r s t o r d e r k i n e t i c s . An o v e r c o a t o f E u d r a g i t n S-100 r e s i n ( 2 % c o a t i n g l e v e l ) c a n e l i m i n a t e t h e f o r m a t i o n of s o f t lumps which a r e commonly o b s e r v e d w i t h EudragitR RS c o a t e d b e a d l e t s . The EudragitH S-100 o v e r c o a t a l s o c o n t r i b u t e s t o r e t a r d d r u g r e l e a s e from t h e c o a t e d b e a d l e t s i n d i s s o l u t i o n media r a n g i n g from pH 1 . 2 t o 6 . 5 .