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FOR reasons detailed elsewhere (Chem. and Iizd., 1953, 1OS9) and contrary to Cookson (ibid., p. 337), Stenlake deduced from the pK',,2 values of lysergic (7.68, 7-96) and isolysergic acid (I) (8.31, 8.60) (see Craig, Shedlovsky, Gould, and Jacobs, J. Bid. Chem., 1938, 125, 289) that the former acid, being the weaker, has the conformation in which the carboxyl group and N<,> are remote from each other; it is here assumed that in both acids ring D has the semi-chair structure (cf. Raphael and Stenlake,

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