Doege-Potter syndrome (DPS) is a rare paraneoplastic condition characterized by hypoinsulinemic hypoglycemia from a solitary fibrous tumor. The underlying mechanism is the secretion of a prohormone form of insulin-like growth factor II (IGF-II) by the tumor, which causes decreased release of glucose into the circulation. We report the case of a 27-yearold Filipino male with presumptive DPS from a recurrent right temporo-zygomatic hemangiopericytoma (HPC). The complexity of DPS requires a multidisciplinary approach. Early screening for metastases from HPC may prevent the undesirable sequelae of the disease process.
The occurrence of breast metastasis from prostate carcinoma and primary breast carcinoma in men may cause a diagnostic dilemma. This report aims to present a patient diagnosed with metastatic castrateresistant prostatic adenocarcinoma who developed breast metastasis mimicking as a second primary. A 57-year-old male patient presented with a breast mass while undergoing hormonal therapy for prostatic adenocarcinoma. The initial histopathologic diagnosis of the breast specimen was an infiltrating ductal breast carcinoma. The breast mass enlarged after four cycles of docetaxel. Immunostaining with prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) was done on the breast specimen revealing a negative PSA and a moderately staining PSAP. These stains confirmed the diagnosis of a breast metastasis from prostatic adenocarcinoma. The differentiation between primary breast carcinoma and breast metastasis from prostate carcinoma is crucial. Hence, immunohistochemistry staining should be utilized for diagnosis and appropriate management.
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