Introduction Recently, the incidence rate of intestinal impairments, such as colon cancer and inflammatory bowel disease IBD , has increased in East Asian countries, including Japan, while that in the Western countries still remains high 1, 2. It is difficult to recover completely from IBD and these patients have an increased risk of developing colon cancer 3. In our previous research, we had suggested that the induction of inflammation-related cytokines has a connection with the formation of aberrant crypt foci ACF , which are precursors of colon cancer 4. Epidemiological studies indicate that colon cancer is strongly associated