The early introduction of solid foods to an infant's diet does not alter growth or body composition during the first year of life and results in a displacement of energy intake from formula. Infants consuming commercially prepared foods have a decreased caloric intake from protein and fat; however, despite this difference, there is no effect on growth or body composition.

Aim. To compare two strengths of a fi xed drug combination (FDC) containing metoprolol XL and amlodipine (metoprolol/amlodipine 50/5; and metoprolol/amlodipine 25/2.5) with its components in hypertension. Methods . We conducted this multicentre, randomized, open-label, trial in Indian patients with hypertension (140 -180 mmHg/90 -114 mmHg) in 11 centres from nine cities. Eligible patients ( n ϭ 402) were randomized into one of fi ve treatment groups (metoprolol XL 50 mg ϩ amlodipine 5 mg, metoprolol XL 25 mg ϩ amlodipine 2.5 mg, metoprolol XL 50 mg, metoprolol XL 25 mg or amlodipine 5 mg) and treated for 8 weeks with fi ve follow-up visits to record blood pressure (BP) and clinical status. Results. At baseline, treatment groups were well balanced; mean Ϯ SD BP was 154.87 Ϯ 11.91/96.63 Ϯ 6.97 mmHg. The greatest reduction in BP from baseline to 8 weeks was seen in the high-dose FDC group (23.61/14.91 mmHg; p Ͻ 0.001). The remaining 4 groups too demonstrated a signifi cant reduction ( p Ͻ 0.001): low-dose FDC Ϫ 22.29/ Ϫ 14.66; metoprolol 50, Ϫ 23.17/ Ϫ 13.37; metoprolol 25, Ϫ 18.41/ Ϫ 12.50 and amlodipine 5, Ϫ 23.01/ Ϫ 13.08. BP reductions by FDCs, however, were not statistically superior to monotherapies. Responder rates (sitting diastolic BP Ͻ 90 mmHg or reduction Ն 10 mmHg) were 93% in the high-dose FDC group and 97% in the low-dose FDC group, and control rates (sitting BP Ͻ 140/90 mmHg) were 66% and 58%, respectively. These rates were higher than that seen in individual components. There were no reports of serious adverse events related to study medications. One each from the low-dose FDC and metoprolol 25 mg group discontinued because of adverse events. Conclusions. FDCs of metoprolol and amlodipine are effective and safe in mild to moderate hypertension.

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