No abstract

A highly efficient and direct methodology for the construction of pyrrolo[2,1-a]isoquinoline, pyrido[2,1-a]isoquinoline, and 12b-H and 12b-OH isoindolo[2,1-a]isoquinolinone alkaloids from commercially available synthons is devised.

The oxidative cleavage of the C-N bond of aryl and heteroaryl (dimethylamino)methyl groups is achieved by employing molecular iodine as a mild oxidizing agent at ambient conditions in the presence...

Lamellarin scaffold is synthesized by a metal free convergent route involving domino Bischler–Napieralski reaction – Michael reaction – oxidation sequence. Six lamellarin analogues were synthesised having substituent on aryl as well as coumarin ring A.

General Information: Reagents were purchased from Sigma-Aldrich and were used without further purification. IR spectra were recorded with Shimadzu FTIR instrument. 1 H & 13 C NMR spectra were recorded in DMSO-d6 with Bruker AVANCE 400 MHz NMR Spectrometer. MS were recorded with Shimadzu LCMS instrument.