Nasopalatine duct cyst is the most common developmental non-odontogenic cysts seen in the midline region of anterior maxilla. An epithelial remnant of the nasopalatine ducts remain in the incisive canal is the most common etiology. Nasopalatine duct cysts are generally asymptomatic and infrequently produce a swelling and associated pain in the anterior palate if secondarily infected. On radiograph it presents with a welldefined round, oval or heart shaped radiolucency. Histopathologically it shows non-keratinized epithelium typically with neurovascular bundles in the connective tissue capsule. Surgical enucleation is the treatment of choice. In the present case report clinical features, diagnosis and management of nasopalatine duct cyst in a 23-year-old male in the anterior maxillary palatal region is discussed.

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Aim: The aim of this study was to evaluate the syndecan-1 expression in oral submucous fibrosis (OSF) according to grades of epithelial dysplasia. Materials and Methods: Twenty samples of OSF were divided into three groups: Group 1 (OSF with mild epithelial dysplasia, n = 15), Group 2 (OSF with moderate epithelial dysplasia, n = 3), and Group 3 (OSF with severe epithelial dysplasia, n = 2). Results: A statistically nonsignificant (P > 0.05) difference was noted when staining intensity of syndecan-1 in stratum basale were compared between OSF with mild dysplasia (O1) and OSF with moderate dysplasia (O2) (P = 0.141), O1 and OSF with severe dysplasia (O3) (P = 0.222) also between O2 and O3 (P = 1.00). A statistically significant (P < 0.05) difference was noted when staining intensity of syndecan-1 in stratum spinosum were compared between O1 and O2 (P = 0.010), O1 and O3 (P = 0.038), between O2 and O3 the difference was not statistically significant (P = 0.414). A statistically nonsignificant difference was noted when intensity of syndecan-1 expression in superficial layers of the epithelium was compared between O1 and O2 (P = 0.655), O1 and O3 (P = 0.715), also when O2 and O3 were compared, the difference was not statistically significant (P = 1.00). Conclusion: Downregulation of syndecan-1 antigen in OSF according to increased grades of epithelial dysplasia correlates to some extent with the disease progression.