entist's or even their own experiments, respectively (Baker and Penny, 2016;Miyakawa, 2020). Among the factors contributing to this reproducibility crisis are selective reporting, low statistical power, or poor analysis and experimental design (Baker and Penny, 2016). In addition, poor starting material -especially for hiPSC research -can be a severe source of irreproducibility (Stacey et al., 2013;Pamies et al., 2017). Therefore, already in 2013 "an urgent need" to establish routine screening methods for the characterization of quality-controlled stem cells was identified (Stacey et al., 2013;Crook et al., 2017).While there is guidance available for Good In Vitro Methods Practices in general (OECD, 2018) or stem cell-based Good Cell Culture Practice specifically (Pamies et al., 2017(Pamies et al., , 2018(Pamies et al., , 2020, giving detailed insights into the broad subject of quality assurance (QA) and quality control (QC) of in vitro (stem cell-based) methods, these leave the average academic researcher with a plethora of QC assays, discussing pros and cons that might or