Pendahuluan. Pasien diabetes melitus tipe 2 (DMT2) pada umumnya memiliki satu atau lebih komplikasi kronik pada saat terdiagnosis. Deteksi dini dan pencegahan sangat penting untuk mengurangi angka mortalitas dan morbiditas terkait DMT2, terutama pada kelompok dengan risiko tinggi seperti anak penderita DMT2. Studi ini bertujuan untuk mencari faktor-faktor yang berkaitan dengan status prediabetes pada anak dari penderita diabetes melitus tipe 2.Metode. Studi ini merupakan studi potong lintang yang melibatkan 54 anak dari penderita DMT2. Subjek dikumpulkan secara konsekutif. Status prediabetes ditentukan melalui HbA1C berstandar national glycohemoglobin standardization program (NGSP). Aktivitas fisik ditentukan melalui kuisioner global physical activity questionnaire (GPAQ)-versi Bahasa Indonesia. Tekanan darah dan data antropometrik diukur secara langsung. Analisis bivariat dan multivariat dilakukan dengan IBM SPSS 23.Hasil. Dilakukan analisis terhadap 54 subjek. Mayoritas subjek adalah perempuan (79,6%) dan rerata umur adalah 38,8 tahun. Proporsi prediabetes mencapai 31,5%. Analisis multiavariat menunjukkan hubungan bermakna antara riwayat paternal DMT2 (adjusted OR 7,520; IK 95%=1,071-52,784), lingkar pinggang berisiko (adjusted OR 5,482; IK 95%=1,019-29,504) terhadap status prediabetes.Simpulan. Riwayat paternal DMT2 dan lingkar pinggang berkaitan dengan status prediabetes pada anak dari penderita DMT2.Kata Kunci: Anak penderita DM tipe 2, HbA1C, intoleransi glukosa, prediabetes The Role of Paternal History of Type 2 Diabetes Mellitus on Prediabetes Status among The Offspring of Type 2 Diabetes Mellitus Patients Introduction. Since patients with type 2 diabetes mellitus (T2DM) often present with one or more chronic complications, at the time of diagnosis, early detection and prevention is essential to reduce T2DM-associated mortality and morbidity, espescially among high risk population such as the offspring of T2DM. This study aimed to investigate several factors associated with prediabetes status among the offsprings of T2DM patients.Methods. A cross-sectional study was conducted involving 54 offsprings of T2DM patients. Subjects were recruited consecutively. We collected demographic data, anthropometric measurement, blood pressure, and HbA1c level. Physical activity were assessed by using Indonesian version of global physical activity questionnaire (GPAQ). Prediabetes status was investigated by standardized national glycohemoglobin standardization program (NGSP) HbA1c. Bivariate statistical and multivariate analysis was performed by using IBM SPSS 23.Results: The majority of subjects were female (79.6%) and the mean age was 38.8 years old. The proportion of prediabetes was 31.5%. Multivariate analysis showed significant association among paternal history of T2DM (adjusted OR 7.520; 95%CI=1.071-52.784), waist circumference at risk (adjusted OR 5.482; 95%CI=1.019-29.504), and prediabetes status.Conclusion: Paternal history of T2DM and waist circumference were associated with prediabetes status among the offspring of T2DM patients.

Indonesia. Surgical management is indicated persistent symptoms despite the initiation of pharmacological treatment. Despite several studies that described preoperative administration of anti-tuberculosis drugs, there was no conclusion about the recommended duration and regiment to reduce the risks of complications.

Objective: Painful and stiff elbow, especially in young patients, results in severe impairment in daily activities. Persistent pain and stiffness despite conservative treatment indicate surgical arthroplasty. Total elbow arthroplasty (TEA) is relatively contraindicated in young patients with high activity due to the risk of early prosthetic loosening. Furthermore, TEA is relatively expensive and inaccessible, especially in developing countries. Interposition elbow arthroplasty has been an alternative to TEA with the possibility of further reconstruction and lower cost. This study aimed to conduct a systematic review of literature evaluating clinical and functional outcomes of various interposition elbow arthroplasty. Methods: We conducted a systematic review to obtain outcomes of interposition elbow arthroplasty. Literature searching was conducted in PubMed, Cochrane Library, and ScienceDirect. We included clinical studies, case series, or case reports related to interposition elbow arthroplasty. Relevant studies were critically appraised by Oxford Central for Evidence-Based Medicine (CEBM) critical appraisal tool. Relevant data including functional outcome, pain, and range of motion (ROM) was then pooled and analyzed. Results: We selected 15 relevant studies including nine retrospective clinical studies, three case series, and three case reports. All studies showed significant improvement of range of motion (ROM) and Mayo Elbow Performance Score (MEPS). The pain score of MEPS also showed improvement in several studies. Pooled study analysis showed an overall Z score of 20.4 (p<0,001) for ROM with a mean difference of 55.5°, Z score of 16.28 (p<0,001) for MEPS, and 9.30 (p<0,001) for MEPS pain score. Conclusion: Interposition elbow arthroplasty significantly improved clinical and functional outcomes postoperatively in patients with stiff and painful elbows.

Telangiectatic osteosarcoma (TOS) is a rare malignant bone tumor. The main clinical and radiological significance of the case presentation is TOS can be easily misdiagnosed as a benign lesion such as an aneurysmal bone cyst (ABC). In this case, we present 63-year-old male with a large mass in the left leg. Imaging modalities were obtained in this patient to define the diagnosis. In this atypical case of TOS, relatively old age presentation, slow-progressing lesion, well-demarcated lesion, and lack of periosteal reaction further accentuate the similarity between TOS and ABC or other benign lesion causing high rate misdiagnosis of TOS. The histopathological examination will finally differentiate TOS from ABC.