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to react with 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one in one hand and 1H-benzo[d]imidazol-2-amine on the other hand to produce Schiff base compounds. Results: Synthesized ether derivative compounds (3a-e) were converted to new series of Schiff bases (4a-e and 5a-e) by condensation of equal molar amounts of compounds (3a-e) with different heterocyclic amines dissolved in absolute ethanol. All synthesized compounds were confirmed by (IR, 1 H-NMR, and 13 CNMR) spectroscopy. All synthesized compounds were evaluated for antibacterial activities in vitro against Gram-positive and Gram-negative bacteria. Conclusion: All compounds were purely synthesized, and all compounds were indicated growth inhibition against Escherichia coli, and Staphylococcus aureus, respectively with different inhibition zones staring from 13 to 33 mm.

A new series of 4-thiazolidinones (4a-j) has been synthesized by cyclocondensation of various acid hydrazones with thioglycolic acid. The intermediate hydrazones (3a-j) were synthesized by the condensation of various substituted benzaldehydes with 4-chlorobenzohydrazide (2). The starting compound 4-chlorobenzohydrazide was prepared from the reaction of ethyl 4-chlorobenzoate and hydrazine hydrate. The structures of the new synthesized compounds had been confirmed by spectral data (FTIR, PP 1 H-NMR, 13 C-NMR, and 13 C-NMR-DEPT and ESIMS). Some of the synthesized compounds (4a-j) were evaluated for their antibacterial activity against Gram-positive bacteria staphylococcus aureus and Gram-negative psedomonas aeruginosa

New 4-thiazolidinone derivatives have been synthesized by the condensation of amino and aldehydes-group containing molecules via the intermediacy of a Schiff base, employing conventional methodologies. Synthesis of new thiazolidinone derivatives was opted for the research work due to their commercial and medicinal importance. The new nuclei were approached by using p-aminoazobenzene. The structures of the synthesized products were confirmed by analytical and spectral data (IR,1H-NMR,13C-NMR, 13C-NMR-DEPT-135,some of the products were screened against different strains of bacteria. Gram +ve S-aureus and Gramve bacteria Pseudomonas aeruginosa.