The antioxidant, reactive species, oxidative stress nexus The term 'antioxidant' is used with ever-increasing frequency in both the popular media and biomedical literature. Notwithstanding its common usage, it can be a difficult term to define precisely. According to one current and useful definition from an authoritative source, antioxidant refers to "any substance that delays, prevents, or removes oxidative damage to a target molecule" (1). In the human body, antioxidants help to prevent, protect, or reduce damage to biological molecules from exposure to specific chemical substances, known as reactive species and which are often generated by endogenous metabolic processes. These reactive species comprise free radicals, such as the hydroxyl radical and superoxide radical, and non-radicals, which include hydrogen peroxide, peroxynitrite ions and hypochlorous acid (2). Notably, the range of biologically important reactive species is believed to be counteracted in vivo by an impressive array of antioxidant biomolecules. These include the antioxidant enzymes: catalase, superoxide dismutase and glutathione Stransferase; endogenously synthesized molecules such as glutathione and thioredoxin; and nutritionally derived antioxidants, such as vitamin C and vitamin E (3, 4). A severe imbalance between the generation of reactive species and their removal by antioxidants can result in a phenomenon typically referred to as oxidative stress (1). Oxidative stress, in turn, has been implicated in the pathogenesis of a wide variety of diseases, such as stroke, diabetes, breast cancer and severe acute malnutrition (5).