Background:Hanging is one of the most common methods of approach in case of suicidal deaths in India. with 83 cases of asphyxial deaths due to hanging. A thorough external and internal examination of ligature mark was performed in all the cases. Results: A total of 83 cases were notified. Majority, 37(44.5%) of cases belong to 3rd decade (21-30 yrs). Males are common victims -52(62.6%). Complete hanging was commonest type -76(91.56%). Chunni was the commonest material -25(31.12%). Single ligature mark was common -80(96.3%). Gross examination revealed soft tissue changes in 23(27.71%) cases. Microscopic examination -breaking, wrinkling and compression of skin along with micro hemorrhages and inflammatory changes in subcutaneous tissues were notified. Conclusion: The examination of corpse in cases of hanging is made easy by correlating current observation with the following finding. The correlation of external, internal and microscopic findings leads to easy formulation of final opinion these cases. It also, to some extent helps to delineate antemortem cases of hanging with postmortem cases. Citation:Arumalla, V.K., et al. Ligature Mark in Hanging -Gross and Histopathological Examination with Evaluation and Review (2016) J Addict Depend 2(1): 65-71.