An exploratory survey was conducted in a top milk pocket area (Sirajganj) to investigate the clinical prevalence of Infectious and non-infectious diseases and disorders (IND) in ruminants throughout the year 2021 in Bangladesh. A total of 755 selected clinical cases were recorded, of which 450 were cattle and 305 were goats, respectively. The selected clinical cases were diagnosed through anamnesis, physical examination, clinical signs, gross pathology or postmortem examination, and clinical examination using common laboratory techniques. A total of 28 infectious and non-infectious diseases and disorders in ruminants were detected, whereas the pooled prevalence (PP) of the infectious disease group in cattle was 38.44%, (95% CI: 33-42) and in goats it was 34.43%, (95% CI: 29-39). Among them, FMD was recorded the highest prevalence at 5.78%, (95% CI: 3.8-8.4) and the lowest prevalence at 0.89%, (95% CI: 0.2-2.1) for Tetanus in cattle. The PP of metabolic disease was 13.33%, (95% CI: 10-16), 12.5%, (95% CI: 9-16) respectively for cattle and goat followed by reproductive diseases 17.11%, (95% CI: 13-20), 16.07%, (95% CI: 12-20). This epidemiological evidence showing the disease burden of cattle and goats in this region will be valuable and provide significant insight to prioritize research on diseases and develop effective prevention and treatment plans. It also serves as a baseline for ongoing epidemiology and prevalence research on diseases in this region.