The present investigations introduce new trend of applying AFM-microscopy to visualize a real 3D-imaging of sample's surface topography. High resolution AFM-investigations indicated that crystalline asprin has regular arrays of atomic arrangement with no violation in the bulk of asprin .TM deflection AFM-gave us good approximation to the diffusion of grain throughout the surface topology of investigated asprin . The AFM-deflection centers imaging indicated that the numbers of grains distribute in circular arrangements on the surface and material bulk .3D-visualized imaging introduce precise determination of exposure surface area interacting with dissolving agent.