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Simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Sulphamethoxazole (SMZ) drug . This method based on the reaction of Sulphamethoxazole (SMZ) with new organic reagent (BYN) it was prepare by reaction between ethyl acetoacetate with 2,4-Dinitrophenylhydrazine. The azo dye product shows absorption maximum at 435 nm. The linearity ranges of Sulphamethoxazole are (2-14 μg.mL-1) with molar absorptivity (14412.77 L.mol-1.cm-1), Sandell's sensitivity index (0.0175 μg.cm-2) , detection limit and Quantification limit ( 0.057, 0.175 μg / ml) respectively. The results showed there are no interferences of excipients on the determination of the drug. The proposed method has been successfully applied for the determination of sulfanilamide in pure and pharmaceutical formulations.

The asymmetric unit of the title compound, C17H13NO2, contains two independent molecules which differ primarily in the rotational orientation of the pendant phenyl group, being conrotatory, with respect to the plane of the quinoline moiety. In the crystal, the molecules form stacks parallel to the b axis through π–π stacking interactions of the heterocyclic rings [shortest inter-centroid distance = 3.5775 (8) Å].