Objectives: To investigate the causes of lower gastrointestinal bleeding (LGIB) in Yemeni patients and to compare our results with the results of other studies. Design: Prospective study of patients with overt LGIB during the period from April 2017 to March 2018. Setting: Specialized center of gastrointestinal and liver diseases in Ibb city, Yemen. Subjects & Method: Consecutive patients who presented or referred to our center with LGIB to whom lower GI endoscopy was performed. Results: During the study period, we had 122 patients with LGIB, 72 were males and 50 were females, with male:female ratio of 1.4:1 The age ranged between 5 and 82 years and the mean age was 45 ± 17.99 years. The clinical presentations of our patients included hematochezia in 72.1%, abdominal pain in 51.7%, diarrhea in 43.3%, pallor, and anemia in 40.2%, weight loss in 39.3%, constipation in 16.4%, bloody diarrhea in 16.4%, and melena in 5.7%. The most common colonoscopic findings were hemorrhoids in 36.7% followed by colon cancer in 19.7% and nonspecific colitis in 15.6%. Conclusion: Hemorrhoids and colon cancer were the most common causes of lower GI bleeding in our patients.