In the science learning process practical always have a significant role especially chemistry learning is completed with practical. Chemistry student's concepts clear after the practical performance in the laboratory. The purpose of this research is to improve the learning process in chemistry by comparing two countries' students' practical skills, especially experimental and manipulative, observation, drawing and reporting, and interpretive skills. This research is an experimental, observation sheet used for data collection, observation sheet was validated by three experts, reliability was checked in one class in both countries and modified for data collection. 71 Pakistani and 70 Indonesian organic chemistry undergraduate students were under observation, independent t-test used for data analysis. According to results, there is a significant difference between Pakistani and Indonesian students' practical skills in general, while according to each aspect Indonesian student's practical skills dominate Pakistani students in experimental and manipulative skills. On the other hand, in observation skills, drawing skills, and reporting and interpretive skills, there was no significant difference found, hence Indonesian and Pakistani students have the same practical skills in the last three aspect. Research can be held with different aspects for different results.
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