Introduction: Osteoporosis is the most common metabolic bone disease and protests include decreased bone mineral and underlying tissue. Due to the prevalence of osteoporosis, especially in women and its complications, a study to evaluate the association of osteoporosis with tooth loss and oral dryness feeling in women with osteoporosis was designed. Materials and Methods:This cross sectional study was performed on 170 women referred to the center of bone densitometry of Fasa city. Data were collected using a valid questionnaire including standard questionnaire of xerostomia and demographic variables, also a clinical examination was carried out for determine the number of missing teeth. Then, the data were entered into the SPSS 19 and were analyzed. P<0.05 was considered as statistically significant. Results:The findings of this study showed that there was significant relationship between osteoporosis and oral dryness feeling (p<0.001). But no significant difference was found between the two groups regarding average number of teeth missing (p=0/09). However, significant difference was found between age and number of missing teeth (p=0/02). Conclusion:The results showed that osteoporosis cannot be considered risk factors for tooth loss. But there is a positive relationship between osteoporosis and oral dryness feeling in women.