The objective of this study is to describe the epidemiological characteristics and the risk factors for voluntary poisoning by pesticides in the Rabat-Salé-Zemmour-Zaer region between 2008 and 2014. This is a retrospective study of cases of voluntary poisoning by pesticides collected between 2008 and 2014 by the Anti-poisoning and Pharmaco-vigilance Center of Morocco. During the study period, 598 cases of voluntary pesticide intoxication were collected. These voluntary intoxications mainly concerned adults whose age is between 20 and 74 years. Female addicts dominated the scene with 61.87% and a sex ratio (F / H) of 2.02 in favor of female sex, with urban predominance. The risk was related to the use of raticides (195 cases). The evolution was favorable in 94% of cases, with 27 people dying during this period.

The aim of this study was to determine the epidemiological profile of accidental poisoning by pesticides. A retrospective study of poisoning cases, declared between January 2008 to December 2014 at the Moroccan Anti poisoning and Pharmacovigilance Center (MAPPC), was conducted. During the study period, 4 110 acute accidental poisoning by pesticides cases were collected. The average age was of patients 19, 24±0,25 years. The sex-ratio (female/male) was 0.95. Poisoning mainly concerned adults between the ages of 20 and 74 (about 43%). The pesticide poisoning occurs more often in European Scientific Journal August 2017 edition Vol.13, No.24 ISSN: 1857 -7881 (Print) e -ISSN 1857 134 urban zones with 54.1%. These were mainly poisonings that occurred at home in 70.5% of cases. Patients were mostly symptomatic (about 65%), these poisonings occurred mainly during the spring mostly in the spring (32%) and summer (29%). Insecticides were the most commonly incriminated in 64, 13% of cases, followed by rats, pesticides, and herbicides with respectively 29%, 3.42% and 0.85%. The declarations came from all regions of Morocco, the highest incidence was recorded in the Tadla-Azilal region (4.04 per 100 000 inhabitants). The Fes Boulemane region showed a significant lethality of 6.43%. Among the 3,077 patients for whom the evolution was known, 98.1% had progressed favorably. 47 cases of death were recorded with a lethality of 1.2%. (Figure 1).Les insecticides étaient les plus incriminés dans 64,13% des cas, suivi par les raticides, les pesticides, et les herbicides avec respectivement 29% ; 3,42% et 0,85%. Les déclarations provenaient de toutes les régions du Maroc, la plus forte incidence a été enregistrée dans la région de Tadla-Azilal (4.04 pour 100 000 habitants), La région de Fes Boulemane a présenté une létalité importante de 6,43%. Parmi les 3 077 patients pour lesquels l'évolution a été connue, 98,1% avaient connu une évolution favorable. 47 cas de décès ont été enregistrés avec une létalité de 1,2 %.

No abstract

Analyzing the spontaneous reports of adverse drug reactions (ADRs) of anti-infective drugs for systemic use is an essential pillar in creating valuable database in pharmacovigilance.Therefore, the main of this study is to describe the epidemiological and clinical properties, as well as, the frequency and profile of ADRs generated by anti-infective treatment, declared at the Moroccan Anti-Poison and Pharmacovigilance Center (MAPPC).A retrospective descriptive study was implemented from the notifications of ADRs generated between 2008 and 2016 and recorded on VIGIBASE. Over the research period, 1161 cases of ADRs reports were declared. The average age was 37.4 years ± 19.52, it’s been noticed that the adults were the most affected in 81.89% of the total cases, with the sex ratio (Female / Male) being 1.34. Antimycobacterials and antibacterials for systemic use were responsible for 68% and 28.3% of the adverse reactions, respectively. 29.76% of the cases showcased skin and subcutaneous tissue disorders and 23.23% of the cases displayed hepatobiliary and pancreatic system disorders. Serious cases represented 30% of all noted cases, including 2 fatalities. In the interest of preventing the risk of adverse reactions originating from the taking anti-infective drugs for systemic use, reporting to the ADRs to the pharmacovigilance system should be highly encouraged.