Our meta-analysis confirms that individuals with the homozygous S allele of 5HTTLPR polymorphism are at increased risks of major depressive disorder as well as alcohol dependence. Further studies are required to investigate the association between 5HTTLPR polymorphism and the comorbidity of major depressive disorder and alcohol dependence as well as gene × environmental interactions.

Bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor (VEGF). Hypertension is a well-recognized, common side effect of VEGF blocking agents. The reversible posterior leukoencephalopathy syndrome (RPLS) has been described as a rare but serious consequence of bevacizumab administration. We present a case of a 6-year-old child with refractory hepatoblastoma who developed hypertensive crisis, seizures and MRI changes consistent with RPLS while receiving bevacizumab with gemcitabine and oxaliplatin. Findings completely resolved without neurologic sequelae with stringent blood-pressure control. Better understanding of risk for RPLS, prompt recognition and aggressive management will be required as bevacizumab gains wider use in pediatrics.

Abstract:Reactive power dispatch plays a main role in order to provide good facility secure and economic operation in the power system. Optimal reactive power dispatch (ORPD) is a nonlinear optimization problem and has both equality and inequality constraints. ORPD is defined as the minimization of active power loss by controlling a number of variables. Due to complex characteristics of ORPD, heuristic optimization has become an efficient solver. In this paper, particle swarm optimization (PSO) algorithm and MATPOWER toolbox are applied to solve the ORPD problem for distribution system with distributed generating (DG) plant. The proposed method minimizes the active power loss in a practical power system as well as determines the optimal placement of a new installed DG. The practical 41-bus, 6-machine power distribution network of Myingyan area is used to evaluate the performance. The result shows that the adjustment of control variables of distribution power network with a new DG gives a better approach than adjustment only the control variables without DG.