Left ventricular aneurysms and diverticula are severe congenital heart defects. The low prevalence and mostly asymptomatic course of these anomalies do not always allow us to suspect these defects in time and to differentiate them among themselves. That is why early detection of pathology with the help of fetal echocardiography is a key factor in determination of the tactics of patients’ management. The paper reviews the literature and describes a complex case of prenatally diagnosed left ventricular aneurysm.

In recent years, the influence of chronic low intensity irradiation on the human body has increased. This is mediated not only by the consequences of technogenic catastrophies, but also due to application of radiation therapy of of radiation usage in industry. Hence, we investigated the influence of 1.4-naphtoquinone and vitamin Е on the nitroso-oxidative processes in the digestive organ mucous membranes, while affected by low intensity X-ray irradiation alone and in combination with the experimental blockage of COX, in rats. Our results show that X-ray irradiation of a total dose of 20 sGy during twenty days, induced an increase of the oxidative processes, as well as an increase in the activity of iNOS and myeloperoxidase in the mucous membranes of the stomach, small and large intestine. Both the effect of vitamin E and a 1.4-naphtoquinone derivative on the background of low intensity X-ray irradiation, and under the simultaneous effect of X-ray irradiation and COX blockage, brought about a decrease of the level of oxidative processes and of iNOS activity, whereas MPO activity increased. We also noted that the effect of vitamin E on the background of X-ray irradiation more significantly increased both the activity of SOD and catalase, when compared to the induced effect of the 1.4-naphtoquinone derivative. Under the conditions of COX-1/COX-2 blockage (as induced by way of indomethacin administration), against the background of X-ray irradiation, the content of TBA-active products (in the stomach and small intestine mucous membranes), the level of iNOS activity and the sum of nitrites and nitrates, were lower than that of independent effect. Тaking into account the prominent antioxidant and anti-inflammatory attributes of 1.4-naphtoquinone-3-[3-(3.5-di-tret-butyl-4-hydroxy-phenyl)-1.4-dihydronaphtalene-2-aminoil] butyrate, when compared to the effect of sole administration of vitamin E, both under the conditions of X-ray irradiation alone, and the simultaneous effect of X-ray irradiation and COX blockage, this derivative may be considered suitable as a perspective radiprotectant.