Chaman fault is a seismically active fault running over 850km in western region of Pakistan and Afghanistan. It is a major geological structure between Indian and Eurasian plates. Chaman fault is a strike slip fault which is slipping nearly at the rate of 10mm per year. This research includes the evaluation of lithological processes and neotectonics activity using Hypsometric Integral (HI). We calculated values of hypsometric integral using SRTM DEM with 90m spatial resolution in active region of Chaman Fault (CF) and in its locality. We analyzed different mean, minimum and maximum elevations using regular square grids and measured the degree of spatial distribution of HI using Local Indices (LI) of Spatial Autocorrelation (LISA). LISA provides auto correlation for the cluster analysis of hotspots and cold spots of HI values to discriminate uplifted and eroded regions.