Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], was extracted form turmeric and also synthesized by the condensation of vanillin substituted by acetyl acetone. Its metal complexes (M = Eu, Ce, La, Y, Cr, Pd) were prepared and characterized by IR and UV-vis spectroscopy. The result shows that curcumin coordinates with metal ions in bidentate mode in deprotonated form. Anti-bacterial study of the synthesized complexes indicated that this complexes has anti-bacterial activity against Klebsiella pneumonia and Escherichia coli. The result of agarose gel electrophoresis suggested that the complexes had good interaction with genomic DNA.

N-Alkynylindoles were divergently cyclized for the synthesis of multifused N-heterocycles. An ortho-aryl palladium species was added to the α position of an ynamine to generate (Z)-6-alkylidene/benzylidene-6H-isoindolo[2,1-a]indoles, while Pt-catalyzed β-addition through π-activation gave 5-alkyl/arylindolo[2,1-a]isoquinolines. Double cyclizations using PdCl and oxidant afforded bright yellow benzo[7,8]indolizino[2,3,4,5-ija]quinolines, the synthesis of which was also demonstrated in a different synthetic route.

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Scheme 3. Cycloisomerization of C3-unsubstituted and C3phenyl substituted indole ynenemines.Scheme 4. Further synthetic transformation of 4 a to biologically active indole analogues.UPDATES

N-Alkynylindoles were divergently cyclized for the synthesis of multifused N-heterocycles.A no rtho-aryl palladium species was added to the a position of an ynamine to generate (Z)-6-alkylidene/benzylidene-6H-isoindolo[2,1a]indoles,w hile Pt-catalyzed b-addition through p-activation gave 5-alkyl/arylindolo[2,1-a]isoquinolines.D ouble cyclizations using PdCl 2 and oxidant afforded bright yellow benzo- [7,8]indolizino [2,3,4,5-ija]quinolines,t he synthesis of which was also demonstrated in adifferent synthetic route.