A simple and efficient approach to enantioenriched α,β-disubstituted γ-butyrolactones has been developed through multifunctional modular organocatalysis in a highly enantioselective (>99% ee) and diastereoselective (>30:1) manner following a one-pot sequential Michael−hemiacetalization−oxidation reaction. The catalytic process has great substrate compatibility, and the products have been transformed to synthetically useful molecules. The methodology has also been applied to the formal synthesis of (+)-Pilocarpine.

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We have developed a highly stereoselective formal [4+1] annulation reaction to construct trans-2,3-dihydrobenzofurans utilising in-situ generated supported pyridinium ylide. This approach has excellent substrate versatility, and gram-scale capability. Moreover, the...

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