Plants are the source of a large spectrum of phytochemicals, and the combined and concerted action of biologically active compounds lead to the potential beneficial properties of each plant matrix. A great attention is being addressed over the years toward herbs and medicinal plants. Dragon’s Blood is a reddish resin oil extracted from Croton lechleri tree. It has been extensively used by indigenous cultures of the Amazon River since ancient times due to the beneficial nutraceutical and pharmaceutical properties. This perspective aims at providing a current framework on Dragon’s Blood with focus on antioxidant properties for nutraceuticals and pharmaceuticals in a novelty integrated and multidisciplinary manner, highlighting the current knowledge, the main research lines, and emerging strategies. A literature quantitative research analysis approach was applied as starting point. The literature search was carried out by means of the Scopus database; 365 documents have been retrieved in the year range from 1854 to 2021, and a total of 269 terms were identified. Among the top-recurring keywords appear: unclassified drug, nonhuman, plant extract/s, Dragon’s Blood, dracaena, Dragon Blood, chemistry, human, animal/s, plant resin. Source, chemical composition, potential nutraceutical, and therapeutical applications of Dragon’s Blood are discussed here. The anti-inflammatory, wound healing, antidiarrheals, anticancer, antirheumatic, antiseptic, and antioxidant activities identified in the Dragon’s Blood extracts can open novel perspectives for its use in food and pharmaceutical industries. While different bioactive compounds have already been identified in Dragon’s Blood extract, only a few studies can be found in literature.