Diet quality is now established as the single leading predictor of perennial premature death in modern countries. However, practice at scale in modern medicine is driven as much by financial as clinical imperatives and yet, the ability to quantify the potential ROI of Food as medicine (FaM) interventions is limited by a lack of data. Utilizing a novel advance in dietary assessment and data from the peer-reviewed literature, we constructed and tested a web-based calculator simulating the return-on-investment associated with FaM interventions.