PFX inverse planning can be performed using geometric isocenter selection and mathematical modeling and optimization techniques. The obtained treatment plans all meet or exceed clinical guidelines while displaying high conformity.

Opportunity exists to decrease healthcare-related exposure to SARS-CoV-2, preserve infection control resources and increase care capacity by reducing the time to diagnosis of COVID-19. We performed a retrospective cohort analysis to measure the effect of targeted rapid molecular testing for SARS-CoV-2 on these outcomes. In comparison to standard-platform testing, rapid testing was associated with a 65.6% reduction (12.6 hours) in median time to removal from isolation cohort for patients with negative diagnostic results. This translated to an increase in COVID-19 treatment capacity of 3,028 bed hours and 7,500 less patient interactions that required consumption of personal protective equipment per week.

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PFX treatment plans with homogeneous dose distribution can be achieved by inverse planning using geometric isocentre selection and mathematical modeling and optimization techniques. The quality of the obtained treatment plans are clinically satisfactory while the homogeneity index is improved compared to conventional PFX plans.

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