No abstract

BACKGROUND:The incidence, prevalence, mortality and morbidity of ischemic heart disease are increasing all over the world. Early detection and prevention of ischemic heart disease is important. Hence, identification of biomarkers for cardiovascular disease and its risk factors is needed. AIMS AND OBJECTIVES: To evaluate the association of Gamaglutamyl transferase activity with lipid risk ratios in ischemic heart disease. MATERIALS & METHODS: This cross sectional comprises 50 healthy subjects and equal number of myocardial infarction cases. Serum gamaglutamyl transferase activity, lipid profile was estimated and lipid ratios were calculated. Data was statistically analyzed. RESULTS: Serum Gamaglutamyl transferase activity increased in myocardial infarction cases and is correlated with lipid ratios. CONCLUSION: Serum Gamaglutamyl Transferase activity may be used in clinical practice as an aid for prediction of ischemic heart disease.

In NIDDM, studies from Steno Memorial Hospital in Denmark and the Joslin clinic in Boston have shown increased coronary heart disease(CHD) mortality compared with the non diabetic population. In the Joslin clinic study, one third of male and female patients with NIDDM died from CHD before the age of 60. Normal cases were 30 and were selected at Random from different wards of Hospital. The venous blood was collected for both fasting and post prandial for blood sugar estimation. The fasting blood samples were collected for the estimation of serum Total cholesterol, serum Triglycerides and serum HDL cholesterol estimation.

Hyperlipidemia in association with insulin resistance is common in patients with type 2 diabetes mellitus. Insulin resistance and the ensuing hyperinsulinemia are associated with hypertriglyceridemia and low serum high-density lipoprotein (HDL) cholesterol concentrations. The lipoprotein abnormalities are related to the severity of the insulin resistance. The venous blood was collected for both fasting and post prandial for blood sugar estimation. The fasting blood samples were collected for the estimation of serum Total cholesterol, serum Triglycerides and serum HDL cholesterol estimation. In this study it was found that though the patients were on oral hypoglycaemic drugs and some patients were on Insulin the fasting blood sugar and post prandial blood sugar are significantly high in study groups when compared to control groups (P< 0.001).