The novel Pyrazoline derivatives were prepared by cyclisation of substituted chalcone derivatives in the presence of 2, 4 dintro phenyl hydrazine hydrate. Structural elucidation of all synthesized derivatives were done by spectral analysis ( IR , NMR and Mass spectroscopy). All synthesized derivatives screened for their anticancer activities by MTT assay and these prepared derivatives exhibits promising anticancer activities.

Autophagy is an intracellular has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps sequestration, transport to lysosomes, degradation, and utilization of degradation products and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in various diseases like Cancer, Neurodegenerative disease etc.