A two-stage operational transconductance amplifier is constructed and compared between 45nm and 180nm CMOS technology in this paper. To find the best design, the suggested operational amplifier is examined across a number of distinct parameters. With a supply voltage of 1.8V, it reaches a maximum gain of about 66 dB and a phase margin of 82°. A Cadence Virtuoso-based circuit simulator has been used to construct the suggested operational amplifier and the comparison is done. Keywords: OTA, Miller coupling capacitance, cadence virtuoso, Gain, output swing, power dissipation.