Few children experience extended bouts of PA, and from 11-13 y, PA decreases, with more girls than boys becoming inactive. The data emphasize the importance of promoting active lifestyles during youth.

A 49 year old man presented with near-fatal, fulminant, haemorrhagic cardiac tamponade. He responded well to emergency pericardiocentesis and subsequent investigation revealed the cause to be an unknown squamous carcinoma of the bronchus with pericardial involvement. He died 13 weeks later. Such a dramatic presentation of this type of tumour in a male patient has not been previously described.

These data are consistent with the hvpothesis that programmed alterations to renal structure are reflected in progressive deterioration HJ NEWBERY', N FISHER^, M PIRMOHAMED", NR KITTERINGHAM' IT GILMORE', D ADAMS3 and BK PARK'Evidence from twin, longitudinal and cross-sectional studies suggests that alcoholic liver disease is multifactorial in aetiology, with genetic and environmental factors interacting in its pathogenesis. A role for TNFu in this process is supported both by observations of raised levels of TNFU, correlating with disease severity, and the association of promoter region polymorphisms with the disease. Furthermore,