Kupipakwa Rasayana is used as therapeutic agents in the Indian system of Medicine, Ayurveda. It is unique due to its method of preparation. Kupipakwa Rasayana are prepared in the specially designed device Valuka Yantra. Parada (Mercury) and Gandhaka (Sulphur) are the chief ingredients in this medicine along with other metals and minerals. These Kupipakwa Rasayana are used in the different disorders like Rajyakshma, Kushtha, Prameha, Arsha, Vatvikara etc. Here in the present study it was decided to screen and review its reported experimental efficacy studies. On screening, it was revealed that numerous Kupipakwa Rasayana showed significant anti-microbial, anti-diabetic, anti-oxidant, immune-modulatory, anti-hyperglycemic properties. The observed encouraging results shows the further scope for broad spectrum research era in Kupipakwa Rasayana.

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