The objective of present study was to formulate directly compressible Oro improved solubility by using solid dispersion technique. Nitazoxanide treatment of giardiasis and crystopordiasis. Solid dispersion of nitazoxanide was prepared by Kneading method and physical mixture using polymer as a carrier and using three different drug:carrier ratios;1:0.5, 1:1 and 1:3.Saturation solubility of drug was determined in physical mixture and solid dispersion. Formulation batches of solid dispersion were characterized by drug content, FTIR Spectroscopy, DSC and nitazoxanideis converted into amorphous state during formulat nitazoxanide were designed using optimized solid dispersion and crospovidone dispersible tablet shows disintegration time 54seconds and dispersible tablet (-) shows disintegration time of60minutes. Thus solid dispersion based oro patient compliance and convenience.