We examined incidence probabilities of cervical intraepithelial neoplasia 3 (CIN3) or more severe lesions (CIN3+) in 1,467 adult Japanese women with abnormal cytology in relation to seven common human papillomavirus (HPV) infections (16/18/31/33/35/52/58) between April 2000 and March 2008. Sixty‐seven patients with multiple HPV infection were excluded from the risk factor analysis. Incidence of CIN3+ in 1,400 patients including 68 with ASCUS, 969 with low grade squamous intraepithelial lesion (LSIL), 132 with HSIL without histology‐proven CIN2 (HSIL/CIN2(−)) and 231 with HSIL with histology‐proven CIN2 (HSIL/CIN2(+)) was investigated. In both high grade squamous intraepithelial lesion (HSIL)/CIN2(−) and HSIL/CIN2(+), HPV16/18/33 was associated with a significantly earlier and higher incidence of CIN3+ than HPV31/35/52/58 (p = 0.049 and p = 0.0060, respectively). This association was also observed in LSIL (p = 0.0002). The 1‐year cumulative incidence rate (CIR) of CIN3+ in HSIL/CIN2(−) and HSIL/CIN2(+) according to HPV genotypes (16/18/33 vs. 31/35/52/58) were 27.1% vs. 7.5% and 46.6% vs. 19.2%, respectively. In contrast, progression of HSIL/CIN2(+) to CIN3+ was infrequent when HPV DNA was undetected: 0% of 1‐year CIR and 8.1% of 5‐year CIR. All cervical cancer occurred in HSIL cases of seven high‐risk HPVs (11/198) but not in cases of other HPV or undetectable/negative‐HPV (0/165) (p = 0.0013). In conclusion, incidence of CIN3+ depends on HPV genotypes, severity of cytological abnormalities and histology of CIN2. HSIL/CIN2(+) associated with HPV16/18/33 may justify early therapeutic intervention, while HSIL/CIN2(−) harboring these HPV genotypes needs close observation to detect incidence of CIN3+. A therapeutic intervention is not indicated for CIN2 without HPV DNA.

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In the tomato plant nutrient absorption is continuous and the net assimilation rate is kept almost constant at 6-7 g•m• 2 •day• 1 throughout growth. The biological and economic yields are equivalent to those of cereal crops. Except for a few leaves at the base, a tomato plant is composed of several units which consist of the stem and three leaves (the vegetative organs), and a truss (the reproductive organ). Vegetative and reproductive growth occur simultaneously. The reproductive growth does not compete with the vegetative growth for nutrient elements or photosynthates because the growth of fruits is achieved by using currently absorbed or,produced substances. The photosynthetic potential of the leaves seems to exceed the requirement of growing organs, and the leaves generally continue to grow even when the fruits are developing 'rapidly.

Multiple primary malignant tumors in the same individual occur more frequently than one would expect, yet metastasis of one cancer to another independent cancer is an uncommonly reported finding. The present report adds to the past literatures a case of metastasis of gastic cancer to hypernephroma and furthermore even to sites of metastasis of hypernephroma. An attempt to clarify the correlation of two tumors and tumor-host relationship was made in comparison with experimental results of transplantable induced double cancer (DAB hepatoma and MC sarcoma) of the rat in our laboratory, CASE REPORTA 65-year-old Japanese male was admitted to the Numata Kosei Hospital on December 30, 1962. Neuralgia of both legs had begun in June, 1962. On admission, he complained of Severe neuralgic pains in the abdominal wall and back, motor paralysis and complete loss of sensitibility of the lower extremities. Disturbances of the vesical and rectal sphincters and atrophy of both legs were noticed. Destruction of the dorsal column X, XI, & XI1 were confirmed by Roentgen examination. Several small subcutaneous nodules were noticed on the chest and abdominal walls. Biopsy of the nodule revealed a metastasis of undifferentiated carcinoma. Indistinct induration was palpable in the upper abdomen. Roentgen examination revealed rigidity of the lesser curvature of the stomach. Clinical diagnosis was then carcinoma of the stomach and its metastases in the skin and dorsal column, resulting in complete transverse interrupture of the spinal cord. Anticancerous agents were ineffective.The patient expired on Feb. 5, 1963, approximately 8months after onset of the symptoms.

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