Background: COUP-TFII, an orphan nuclear receptor, regulates the differentiation process in various cell types during development. Results: COUP-TFII inhibits Runx2-dependent osteocalcin transcription through physical interaction with Runx2 and matrix mineralization. Conclusion: COUP-TFII is a negative regulator of osteoblast differentiation. Significance: COUP-TFII has therapeutic potential for controlling bone-related disease.
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